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Clozariles or clozapine is an antipsychotic medication. It can be used as a cure for schizophrenia, bipolar disorder and other mental disorders. It was originally a hypnotic (manipulating) drug that was introduced into the U.S. by Dr. Van Buisseil in 1963. Since then, it has been prescribed to treat a variety of conditions such as migraines, sleep disorders, Parkinson's disease, obsessive-compulsive disorder, catatonia, obsessive-tic disorders, restless legs syndrome, and more.
Clozapine, despite its name, is not a tranquilizer. Instead, it is an antipsychotic that controls symptoms of anxiety, depression, mania, and other mental illnesses. It can also be used to treat fluid retention, gastrointestinal problems, and frequent urination. In addition, clozapine is frequently used to control the side effects of antipsychotic medications used to treat schizophrenia. Clozapine is also commonly used to treat patients who are on long-term medication for high blood sugar.
So what is clozapine and how does it work? Dr. David Doraiswamy says that clozapine reduces dopamine levels in the brain and as a result causes patients to have fewer mood swings and less severe irritability. He also claims that clozapine "knows" the brain's electrical activity and so if the patient goes into a panic attack, clozapine stops it dead in its tracks. He also says that clozapine is "natural" and is not chemically manufactured like many other medicines.
Doraiswamy isn't completely wrong about clozapine being natural and "natural." Some plants have been modified a little bit to create medicines that are even more effective than their original counterparts, but this doesn't make them "natural" per se. If anything, modifying a plant may give it a longer shelf life and allow it to be sold without a prescription, but chemically modifying or "discovering" a plant is a risky business. It's not clear whether clozapine was chemically modified by the scientists who created the original antipsychotic drug or whether the modification was done by unscrupulous marketers who dreamed of a cheap alternative to Risperdal (the original antipsychotic used to treat psychotic depression) and decided to try it.
The risk associated with taking clozapine, especially for someone who is already at risk for depression or a severe mood disorder, should be discussed before any patients begin to take it. Clozapine has been associated with cases of mania and hallucinations in some patients, and these can be very disturbing to the patient. It's not clear why clozapine can be linked to such side effects, but it is something to be considered. In addition, clozapine can be linked to abnormal heart rhythms, seizures, and comatose. Because the drug is usually given intravenously, the patient must be monitored carefully and administered a high dosage if he or she begins to show these symptoms. Some patients do well on clozapine, but others don't, and these are patients whom the doctor and the hospital ethics require to carefully monitor.
Patients who find that clozapine doesn't work well enough to relieve the symptoms of a psychosis related to depression or schizophrenia may be given a second drug to help them. This second medicine is called risperdal and can be used in conjunction with clozapine. To some patients, clozapine may not work at all because their brain chemistry is already in a state of flux when taking the drug, making it ineffective when additional medications are added. This is why taking risperdal along with clozapine is sometimes recommended.
If clozapine does not work for a patient's mental illness, other options may be considered. The first thing a doctor will want to do is to screen patients for depression and schizophrenia and any other mental illnesses that may be present. When these issues are detected, other treatment plans will be discussed. It is important for patients to understand these plans before taking clozapine, as there may be serious side effects if the wrong drug is taken. These drugs should also be prescribed by doctors who specialize in psychiatric issues because they are more likely to produce side effects than generic drugs. Some patients can be very sensitive to dispersal, and other antipsychotic medicines, and should only be prescribed these if the doctor feels they are suitable.
Clozapine is a powerful medicine, but as with all medicines, there can be side effects. If clozapine does not work for you, try waiting to see if the problem clears up or seek other help from a psychiatrist or psychologist. There can be serious side effects when taking clozapine, and you should not take it if you have other problems such as allergies, stomach problems, breathing problems, bone disorders, or heart problems. If you experience any of the symptoms listed above, stop taking the drugs immediately and contact your doctor or poison control center for advice.